Robert J. Genco Distinguished Speaker Series
Thurs., Oct. 29, 2020
8:45am-11:45am (3 CE hrs)
Speaker: Thomas Van Dyke, DDS, PhD
Recommended for: Everyone
Recent studies have suggested a relationship between oral infection; in particular periodontal disease and systemic diseases. Epidemiologic studies have implicated periodontal disease as a risk factor for the development of cardiovascular disease and stroke, and studies in diabetics have revealed that untreated periodontal disease can lead to diabetic complications and have a direct impact on glycemic control. It has become clear in recent years that periodontitis is an inflammatory disease that is linked to dysbiosis of the oral microbial biofilm. This distinction implies that it is the host response to the biofilm that destroys the periodontium in the pathogenesis of the disease. It is now clear that oxidative stress related to excess inflammation plays a role in the pathogenesis of periodontitis. However, there is limited data on the ability of antioxidants used therapeutically to significantly alter the course of local periodontitis or the associated systemic conditions. As our understanding of pathways of inflammation has matured, a better understanding of the molecular basis of resolution of inflammation, which is distinct from pharmacologic anti-inflammation, has emerged. Resolution of inflammation is an active, receptor agonist mediated well-orchestrated return of tissue homeostasis, not inhibition of proinflammatory pathways, that includes significant reductions in oxidative stress. The mechanism is not scavenging of oxidants, but rather prevention of their production. The isolation and characterization of endogenous lipid mediators of resolution, called lipoxins and resolvins, has opened new doorways for the management of periodontitis and systemic inflammatory diseases. This presentation will review resolution of inflammation, and the role of inflammation and its control in the link between periodontal inflammation and inflammatory systemic diseases (including type 2 diabetes), cardiovascular disease and others.
- Understand the relationship between inflammation, bone loss and tissue regeneration in periodontitis.
- Explain the mechanism of action of periodontal regeneration; why it works and doesn’t work in different situations.
- Discuss potential modifications of treatment regimens for the patient with periodontitis to control inflammation, prevent further damage and achieve true periodontal regeneration.
- Understand the biologic basis of the relationship between periodontitis and systemic disease.
- Develop a working knowledge of inflammatory interactions leading to and linking the common diseases of aging.
- Discuss the modifications of treatment for the patient with periodontitis and complicating systemic disease.
Thomas Van Dyke, DDS, PhD, Vice President for Clinical and Translational Research, Forsyth Institute, Cambridge, MA; Professor, Faculty of Medicine, Harvard University; DDS, Case Western Reserve University; MS, SUNY at Buffalo; Periodontics Certificate, SUNY at Buffalo; PhD, SUNY at Buffalo; Balint Orban Memorial Prize; Diplomate, American Board of Periodontology; IADR Award for Basic Research in Periodontology; Norton Ross Award; William J. Gies Periodontology Award; 340+ original articles.
Dr. Van Dyke is not associated with, employed by, nor consults for any manufacturer, supplier, or retailer of dental instruments or materials.